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Health Guide Review: 3,4/5


Synedrex Review: Does it work?

Intro: What is it?

Synedrex is a weight loss pill with thermogenic ingredients made to help burn fat. It’s supposed to be useful for increasing metabolism, which in turn increases the loss of calories alongside a diet and exercise plan.

It claims to be less likely to produce jitters than other thermogenic formulas. It’s also meant to increase mental clarity, and it’s intended to improve overall mood. The brand promises to provide a proprietary formula to trim and make one look more ripped. Anther intended benefit is appetite suppression and better processing of fats and sugars. Are all these claims actually true? What kind of an effect is possible through this thermogenic? This Synedrex review provides all the information you need to know to make an informed decision.

Synedrex Ingredients

Niacin 100% Pyridoxine HCI 212% Cyanocobalamin 1,666% Chromium Polynicotinate 146%
Methylxanthine Sulbutiamine Saldalwood Extract Yohimbine Extract
Alpha Lipoic Acid Poly-Thyronine DiPotassium Phosphate MCMC
Silicon Dioxide Magnesium Stearate Titanium Dioxide FD&C Blue #1
FC&C Green #40 Gelatin

Methylxanthine: Stimulants such as caffeine and throbromine are made from this base. It’s used to provide stimulant effects and open up the lungs to allow for more airflow. Though it’s considered to be the last solution for these benefits since it’s known to be both ineffective or side effect causing. Web MD mentions:

actions of methylxanthines are not completely known”

It’s known to potentially cause the following side effects:

  • Nausea and difficulty eating.
  • Seizures and muscle twitching.
  • Irregular and or increased heart rate.
  • Stomach nausea and heartburn.
  • Insomnia and restlessness.
  • Nervousness and or irritability.

Sulbutiamine: Synthetic ingredient made up of vitamin B1. It’s used to reduce fatigue; however, it’s unknown how to safely take this ingredient or what a proper dosage is. It’s not well studied and some reports add that it’s important to take it with caution.

Saldalwood Extract: Often used as fragrance oil, it’s often taken as either an antiseptic or as support to the immune system. It’s unknown what kind of an effect long term use can lead to, and it’s known to cause several side effects:

  • Blood in the urine.
  • Nausea and upset stomach.
  • Kidney damage.
  • Allergic skin reactions.

Although not well studied, the damaging effects on the kidney have been noted in more than a few cases.

Yohimbine Extract: Extract found in tree bark which is often used to promote sexual function. It’s used as a fat burner though it has a high rate of potentially causing anxiety. There are also many studies which show the amount added in supplements is often wrong.  Supplement companies often add too much or too little than what’s represented in the supplement facts label.

Alpha-Lipoic Acid: Fatty acid that is used to create energy from glucose.  It can potentially lead to many side effects:

  • Fatigue and restlessness.
  • Diarrhea and gastrointestinal issues.
  • Dangerously low blood sugar.

As far as evidence, Web ME mentions:

health benefit of supplemental ALA has been inconclusive.”

Poly-Thyronine: A kind of thyroxine which is a hormone that the thyroid gland makes for metabolism. No information exists online on whether or not this ingredient is useful for weight loss. Studies are inconclusive on what a safe amount is.

FC&C Green 40: Nowhere is there any information into what this kind of food coloring is. There exists Green 3 and Green 4, and many food colorings are described as being FD&C, but nowhere is there mention of Green 40 or FC&C.

Food coloring of all kinds have been criticized for what some claim is able to cause hyperactivity. The Center for Science in the Public Interest has petitioned the FDA to ban food coloring since they’re known to potentially cause tumors.

Synedrex Quality of Ingredients

There are over 100% of vitamins B12, B6, and the mineral chromium; this high amount can potentially lead to side effects.  Also, MCMC and FC&C Green 40 aren’t mentioned anywhere but on the official website. No evidence exists anywhere on what these ingredients can do, and whether or not they’re safe.

The other ingredients are either unproven to be beneficial for weight loss, or they’re known to cause side effects.

The Price and Quality of Synedrex

The company suggests a maximum of 2 capsules a day, but they also add it’s likely one should be enough. A 45 capsule bottle retails for $52.99. This means the daily price is equal to:

$52.99/22.5= $2.35 for one full daily serving.

There are far too many unanswered questions. Although the company mentions there are clinical studies for the individual ingredients, they fail to provide any proof.

Also, many of these ingredients have been shown to be either ineffective for weight loss, or they’re known to potentially cause unwanted side effects.

Over 100% of Additives

1 capsule provides s a high amount of the following:

Pyridoxine HCI 212%:  Kind of vitamin B6 that is often given in exact doses in order to prevent side effects. It can lead to serious side effects in large amounts:

  • Tingling and numbness in the arms and legs.
  • Difficulty breathing.
  • Scratching and swelling in the throat face, and tongue.

Cyanocobalamin 1,666%: A form of vitamin b12. It’s added in such a high amount that it provides 1,666% of the daily amount in a full serving.  This high amount is known to potentially increase the risk for:

  • Rashes and itching.
  • Extreme thirst.
  • Facial swelling and redness, hives.
  • Swelling in the arms, legs, hands face, and feet.

Chromium Polynicotinate 146%: Used to increase the usefulness of insulin. This is intended to regulate the metabolism of macronutrients.  It’s known to increase the damage to already existing liver or kidney issues.  Other side effects can include:

  • Blood disorders.
  • Mood changes.
  • Impaired thinking.
  • Dizziness and headaches.

Since there’s an excess amount which surpasses the daily recommended limit, it may produce a combination of the listed side effects.

Unknown Ingredients

There are 2 ingredients in MCMC and FC&C Green 40 which are never explained or available anywhere but in Synedrex.

No explanation or clinical studies about these 2 ingredients are available anywhere. It’s unknown if these are made by the company specifically, in either case they fail to explain their purpose. FC&C Green 40 is a food coloring, but coloring agents have to be approved by the FDA. Many food colorings have been banned in the past due to their effects on leading to organ damage

Food coloring has been criticized by the Center for Science in the Public Interest for its potential carcinogenic effects.  They mention that

“disturbing behavioral problems caused by artificial food dyes”

Some dyes are also more potentially carcinogenic then others.

It’s unknown exactly what MCMC is used for, though since it’s an inactive ingredient it’s likely that it’s included to make the pill easier to swallow, or to give it a certain appearance.

Business of Synedrex

The company is Metabolic Nutrition and their customer service line can be reached through the following:

Phone Number: (954) 533-9256

Address: 10318 Nw 55th St

Sunrise, Florida 33351

Though the company has been around since 1998, not much information exists about their business practices. It’s unknown how they operate or what kind of standards they offer.

They do mention a 30 day money back guarantee is offered, but it’s unknown if this has been upheld.

Customer Opinions of Synedrex

Not many reviews are available online. Here’s a summary of the few available customer opinions:

“felt like I was going crazy”

“I wouldn’t recommend this to anyone”

“constant headaches and heartburn”

“started feeling faint, dizzy, sweaty, nauseous”

This brand had a major change in ingredients where none of the original additives are found in this new formula. When looking for reviews both the old and new formula was criticized for side effects.

Many report they felt light headed and weak and some add they couldn’t go to sleep.


There are several key points to consider about Synedrex:

  • Very few reviews are available, and most of the, are negative: The majority of opinions are limited to people either claiming they felt side effects, or that they noticed an increase of energy without any weight loss benefits. These same people also mention they took it according to the recommended dosage, and they even included diet and exercise. Many people have complained about the past formula, and there’s still the same complains about the new version. These handfuls of reviews aren’t enough to fully understand what kind of long term effects the brand may have. The people who disliked Synedrex also mentioned they only were able to take it for a short period.
  • It’s unknown what some of the ingredients are used for: 2 ingredients aren’t explained at all as to their intended purpose. When searching for clinical studies on them online or even any sort of information, its clear these additives aren’t featured anywhere. The company does mention they have in house scientists which formulate their brands, but it’s unlikely they created any new ingredients since they would require FDA approval. Food coloring is one major ingredient which has been shown to be carcinogenic in some forms. Some food colorings have even been banned, and there are current scientific groups who are petitioning to have them banned due to their possible side effects. Food coloring has no nutritional or weight loss function and it’s unknown what MCMC is used for.
  • Many of the ingredients haven’t been proven to be safe or effective: All the ingredients added are either added in such a high amount that they can produce side effects, they have no weight loss function, or they’re known to potentially cause side effects. The company does mention that it’s advised to cycle this brand much like other thermogenic, and they also claim diet and exercise are needed. Still, some of these ingredients are added in high amounts that are often specifically recommended by a doctor to match an individual’s needs. The product at 2 pills a day far surpasses the daily limit for Chromium, vitamin b12, b6, and niacin.
  • The company offers no clinical studies: There’s mention that clinical studies went into individual ingredients, however no studies were performed on the entire formula. Still, even these individual studies aren’t provided anywhere. It’s unknown if they truly exist or what the studies showed. Looking at this clinical information is important in order to understand why the company selected these additives. After researching the ingredients it became clear that the overall consensus is that the additives are either potentially harmful, or they haven’t been proven to be effective for weight loss. The lack of clinical studies and very few customer reviews makes it impossible to accurately judge what kind of long term effect it may have. All that’s known is that clinical studies on the individual ingredients have been lacking.
  • It’s advised to cycle between 8 to 12 week periods: In order for the body to reset itself, the company mention to take a break every 8 to 12 weeks. They don’t go into detail as to what they mean by resetting. This cycling process if often done on stimulant heavy formulas since it can produce either long term side effects or the positive effects may be greatly diminished. It’s unknown which of these is an issue with Synedrex.  Stimulant formulas can produce unwanted side effects in people when taken at certain dosages. It’s unknown exactly what kind of an effect this brand may have since it’s not explained in detail. Taking a week off every 8 to 12 weeks is also advised since it can cause side effects, though the company fails to cite what kind of symptoms are possible.

The majority of reviews on this brand are extremely negative; they range from those who couldn’t handle the side effects, to those who felt it didn’t do much to help in weight loss.

The company adds potentially dangerous amounts of ingredients which may cause unwanted side effects. There’s also the concern due to the lack of clinical studies, even though the company claims there are studies available.

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