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Health Guide Review: 3,1/5


LIPO-6 Review: Does it work?

Intro: What is it?

LIPO-6 is a weight loss pill featuring stimulant ingredients made to be easily absorbed.  These liquid capsules are said to be quick at reducing body fat.

The company claims that pharmaceutical strength ingredients are included that can promote efficient and fast acting weight loss. Since it does contain stimulants, it’s advised to limit use to 8 weeks and to not take stimulants from any other sources including foods. It’s also revealed that this brand won a fat loss support award for 4 years straight. Is the stimulant formula safe and effective? What kind of results does LIPO-6 provide? Continue reading to get the full review.

LIPO-6 Ingredients

Caffeine Anhydrous USP 200 mg Synephrine HCL 20 mg Synthetic 99% Guggulsterones Z&E 1:1 20 mg Bioperine 5 mg
Yohimbine HCL 3 mg Glycerin Vegetable Cellulose Purified Water
Polysorbate 80


Caffeine Anhydrous USP: Dehydrated caffeine that is certified by the United States Pharmacopeia. 200 mg of caffeine are in each serving, which is half the recommended caffeine limit the FDA suggests. One full daily serving provides the maximum limit of 400 mg. It’s known to potentially lead to tolerance and the following side effects:

  • Headaches.
  • Dehydration.
  • Diarrhea and vomiting.
  • Increased heart rate and cardiovascular problems.
  • Muscle twitching and jitters.
  • Cold sweats and trembling.
  • Mood swings. 

Synephrine HCL: Water soluble form of Synephrine which is a stimulant found in bitter orange.  Although it’s used as a fat burner, the National Center for Complementary and Integrative Health mentions as far as health claims there’s:

not enough scientific evidence”

Also, when judging its safety, it has been shown to lead to:

fainting, heart attack, and stroke in healthy people”

Other side effects can include anxiety, panic, paranoia, increased heart rate, and mood swings.

When combined alongside caffeine it’s known to further increase the risks for cardiovascular problems. adds that there are:

“numerous case reports of adverse cardiac reactions”

They also add that studies have been limited, and it’s unknown what kind of a long term effect it may have.

Synthetic Guggulsterones: Man made extract of the guggul tree which is used to lower cholesterol, reduce swelling, and improve thyroid function.

They provide a synthetic version since guggul is becoming extinct. mentions it’s:

not effective for… (fatloss)”

Possible side effects can include:

  • Hiccups.
  • Allergic reactions including itching and rashes.
  • Headaches.
  • Upset stomach, vomiting, diarrhea, and nausea.
  • Muscle breakdown.

Yohimbine HCL: Extract found in the bark of the Yohimbe tree. It’s used to burn fat and it provides an increase in blood pressure. It’s known for its potential high risk for anxiety.  Other side effects may include:

  • Negative reactions with other medications.
  • Suicidal thoughts and manic psychosis.
  • Rapid heart rate.
  • Allergic reactions including swelling in the throat. mentions that when this is included with other stimulants, it’s important to limit intake to just half a serving. This is because the combination of Yohimbine HCL with other stimulants can greatly increase its effects on blood pressure and heart rate.

Polysorbate 80: Inactive ingredient used to stabilize liquid formulas. A study by Nature showed it lead to:

low-grade inflammation and obesity/metabolic syndrome”

This study showed that it harmed healthy gut bacteria, leading to an increase in obesity.

LIPO-6 Quality of Ingredients

4 of the 5 active ingredients have been shown in clinical studies to lead to side effects, 3 of these are stimulant based symptoms. This can include rapid heart rate, mood swings, nausea, and insomnia.  When combined together the stimulant effect is greatly increased, this can amplify possible side effects.

There’s also a heavy dose of caffeine which may also cause unwanted effects.

When mixing these types of ingredients it’s impossible to know how it might react with one’s own body. It’s a potentially dangerous mixture which hasn’t been clinically studied as a whole.

The Price and Quality of LIPO-6

Purchases made through the manufacturer sell for $44.95 per 120 capsule bottles. Since it’s advised to take a maximum of 4 capsules a day, one bottle provides a month’s supply at the daily price of:

$44.95/30= $1.49 for a full daily serving.

The stimulant mixture is all known to be potentially dangerous on their own. Also, there’s an inactive ingredient in Polysorbate 80 which can actually increase weight gain.

The company claims that LIPO-6 is better metabolized by the body. No proof is provided to show if this pill absorbs any better than other formulas.

Unproven Claims

Many promises are made that include:

“rapid and healthy weight-loss”


“pronounced fat-loss”

These are all specific but there’s no evidence provided to show exactly what they mean by this. Since the company claims that LIPO-6 can produce these results, that means they’ve tested it.

However, these studies are never provided. So either the company is being untruthful, or for some reason they don’t want to cite their proof.

There’s also no money back guarantee offered, so any purchases made are final.

The company also mentions that this brand is the:

“4x award winning fat-loss support product of the year”

It’s never explained in detail how they won this award or who gave it to them. No information exists on what organization gave them this prize.

Another claim is:

“Do not use for more than 8 weeks”

It’s important to understand why this specific number was given. I couldn’t find any research into why the ingredients added would be reduced to an 8 week period.

Clearly since they gave a specific number there has to be a reason.

High Amounts of Stimulants

A full serving of LIPO-6 provides the daily maximum limit of caffeine for the average person. The company makes sure to give notice by adding a warning on each bottle which reads:

“Do not use for more than 8 weeks”

The company doesn’t say why, but it’s likely to be for one of 2 reasons:

  1. It loses its potency after repeat use.
  2. It’s potentially dangerous long term.

Those are the likely reasons why a limit is set at 8 weeks. They also mention not to consume caffeine or stimulants from any other sources including coffee, tea, and energy drinks.  This is so you don’t pass the daily limit on caffeine which is recommended at 400 mg. LIPO-6 has 400 mg per one full daily serving.  Taking more caffeine can cause serious side effects that include:

  • Chest pain.
  • Ringing in the ears.
  • Withdrawal symptoms.
  • Increases risk for seizures.
  • Grinding of the teeth.
  • Flu like symptoms.

In combination with the other ingredients such as Yohimbine HCL, and Synephrine HCL, it might worsen these symptoms. Not everyone reacts to stimulants the same, and for some people smaller amounts can stimulate the body too much.

Business of LIPO-6

Nutrex Research Inc. can be reached below:

Phone Number: (407) 359-0734

Address: 579 South Econ Circle

Oviedo, Florida 32765

They’ve had problems in the past due to issues with their supplements:

  • A warning letter was sent from the FDA due to health concerns. The company claimed that their DMAA found in previous batches of LIPO-6 were safe. The FDA mentioned that there’s no proof to suggest that it’s a safe additive. It was also added illegally. The FDA required the company to stop adding this ingredient. It was banned due to its high risk for heart attacks, shortness of breath, and chest pains. The company sent a letter back claiming it’s safe to use, but they failed to provide any proof. 
  • They were sued via a class action lawsuit for health risks found in LIPO-6.

Customer Opinions of LIPO-6

The company doesn’t provide any testimonials for LIPO-6, but there are multiple online reviews available:


“Zero Results”

“did not see any changes in weight loss”

“made me dizzy and gave me a rapid heartbeat”

Most customers agree that there’s no weight loss potential. Even to those who exercised and calorie counted, they still failed to see any weight change.

There have also been reports of side effects. This is common in the kinds of stimulants added.  Most have complained about rapid heart rate, anxiety, jitters, and insomnia.


Several important points need to be considered about LIPO-6:

  • 4 out of 5 active ingredients can promote side effects: Yohimbine HCL, Synephrine HCL, caffeine, and Guggulsterones have been shown to cause side effects in some. Some customers also add that they experienced symptoms including rapid heart rate, anxiety, jitters, and insomnia. Determining how one may react to this mixture is unknown since no clinical studies are provided by the company. When mixing stimulants the effects are increased especially these types of ingredients. The amount of caffeine added provides the full daily limit recommended by the FDA. When having high amounts of stimulants it’s important to watch for intake as it may cause dangerous symptoms.
  • There’s no evidence provided by the company: There’s many claims made about the speed that this brand works, and it’s also supposedly a groundbreaking weight loss supplement. No proof of this is provided anywhere. With these types of claims it’s likely that research had to be done to showcase the exact rate and effectiveness. Otherwise, the company is making faulty improvable claims. They were cited by the FDA before due to health claims made about 5 of their supplements including this one. They also claim that this brand has won 4 consecutive years as the weight loss product of the year. It’s never revealed who gave them this award, or what other supplements were observed. Many claims are made by the company and not one of them is backed by any proof. They also fail to provide a money back guarantee.
  • Previous versions of this supplement included banned substances: The FDA sent a warning letter due to the previous version of LIPO-6 containing a banned ingredient. The company sought to fight back, claiming it was sourced from all natural ingredients. However, the side effects that were possible include heart attacks and death. It’s unknown why they would try and sell a potentially dangerous brand. The company now makes this new version of LIPO-6, but they don’t offer any proof to show whether or not it’s safe. Without being able to determine what kind of an effect this blend may have, it’s a potentially risky supplement. In reading the ingredients many of these additives need to be taken with extreme caution since they can create more pronounced effects when mixed. No clinical evidence is available to detail what kind of an effect this stimulant heavy formula might have.
  • It provides the daily limit for caffeine: A daily serving has the advised limit of caffeine consumption. The warning label on the product mentions to avoid any other forms of stimulants including caffeine. They also add that one should only use it for 8 weeks maximum. They don’t explain why, but it’s likely due to tolerance or side effects. Since the company established a limit it’s important for them to cite their sources. They don’t offer any evidence to show why this specific limit is set. Also, it makes it impossible to use this brand as a long term solution. One has to take breaks in between to avoid possible issues. No explanation is given as to how long one should take a break for.
  • Many customers have complained about a lack of weight loss: The most common negative review is from customers who failed to see any changes. Several of these people also mention how they included diet and exercise. The company mentions that LIPO-6 works “almost immediately”. It’s not explained what this means exactly. Without an explanation it’s impossible to judge why so many have failed to see any weight loss benefits.

There’s no proof provided by the company and most customers agree there’s either no change in weight loss or only side effects.

LIPO-6 has a high amount of caffeine and other stimulants which may cause side effects. There’s also no money back guarantee offered, and no proof of safety.  Mixing this high amount of stimulants can be potentially dangerous.

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