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Health Guide Review: 3,3/5


Leptigen Review: Does it work?

Intro: What is it?

Leptigen is a weight loss pill claiming to provide safe and results.  It has a proprietary blend of ingredients, 2 of which are patented.

The intended benefit is to help burn calories faster, increase metabolism, and to provide an extra boost of energy. Clinical studies were also performed on individual ingredients. According to these studies, people lose more weight when using these ingredients then when a placebo is used. The way the brand is meant to work is by releasing fat in the body and increasing overall metabolism. How well does this brand actually work? Are the clinical studies on individual ingredients actually useful? This review provides all the information you need to know about Leptigen.

Leptigen Ingredients

Green Tea Extract standardized to 70% EGCG Meratrim 400 mg Chromium Polynicotinate ChromeMate 100 mcg Natural Caffeine USP 75 MG
Gelatin Cellulose Silicon Dioxide Magnesium Stearate

 Green Tea Extract: This common tea provides the antioxidant EGCG, which is used to treat many different diseases.  According to the National Center for Complementary and Integrative Health, the effects on reducing weight and blood cholesterol have been studied and there’s:

not enough reliable data to determine whether Green Tea can aid”

They also add there should be caution since there’s been:

reports of liver problems in people taking concentrated green tea extracts”

It’s also known to potentially increase the risk for:

  • Nausea and upset stomach.
  • Insomnia and restlessness.
  • Diarrhea and frequent urination.

Meratrim: A patented blend of mangosteen which is a tropical fruit, and sphaeranthus indicus, an herb found in Ayurvedic medicine.  Web MD mentions mangosteen is often used for diarrhea treatment and there’s:

no scientific information about whether mangosteen works”

This also includes a lack of safety reports.

Sphaeranthus indicus is greatly under researched, and it’s unknown if it’s effective for its claims of reducing allergies and blood sugar.  A joint study performed by the Department of Pharmacology and the G. H. Paten Institute of Pharmacy showed that this herb lacks sufficient studies on the:

clinical, toxicity, and phytoanalytical properties”

This means that the overall safety is unknown, and it could be a potentially dangerous additive.

Natural Caffeine USP: Pharmaceutical grade caffeine used to promote a stimulant effect.  The company mentions that just enough is added to prevent jitters and to promote the metabolism of fatty acids.

2 full doses of Leptigen provides 150 mg of caffeine, 400 mg is the daily limit advised by the FDA. Caffeine can potentially cause side effects including:

  • Headaches and migraines.
  • Mood swings, depression, and negative emotions.
  • Nausea, vomiting, diarrhea, and gastrointestinal issues.
  • Rapid heart rate and increased blood pressure.
  • Muscle twitches, jitters, and spasms.
  • Muscle cramps and aches.
  • Cold sweats and clammy skin.

Caffeine also has a limited effect on weight loss, repeat use leads to a loss of any of the health benefits except sleep loss.

ChromeMate: A mixture of chromium and niacin that’s meant to stabilize blood sugar levels.  This patented mixture was created by the InterHealth Nutraceuticals group. One clinical study performed on 20 obese people who included exercise did see more weight loss than a placebo. However, more unbiased studies need to be performed on more people to prove it’s effective and safe.

Leptigen Quality of Ingredients

The caffeine added may produce side effects and it’s only a short term solution to minimal weight loss.

ChromeMate is not well studied enough through unbiased studies, and Green Tea has not been proven to be effective for weight loss. Finally, the ingredients in Meratrim are understudied, and it’s unknown if they have any positive or negative effects.

The Price and Quality of Leptigen

If purchased through the manufactures a 60 capsule bottle lasting a month costs $109.95.

This means the daily price at the recommended 2 pills a day will equal:

$109.95/30= $3.66 for a one day full serving.

It’s advised for best results to exercise often and to exclude junk foods, introduce 8 glasses of water a day, and eat more vegetables and fruits.

This price is expensive for what you’re getting. Green Tea extract is not proven to be effective and it’s available much cheaper. Caffeine can be also found through cheaper sources.  Meratrim and ChromeMate both have flaws. Meratrim’s ingredients when tested alone have yet to be studied enough.

ChromeMate has two ingredients mixed which are often found in whole food. Many customers have mentioned that the ingredient mixture is much cheaper when bought on their own.

Clinical Studies on Leptigen

The company often mentions that ingredients in Leptigen have been proven to be effective for weight loss. They also mention hints that Leptigen was tested, but they never cite these studies.

They add:

“Many people report seeing a difference within the first month”

Though they never cite studies to prove this claim. It’s unknown what kind of results were seen and whether or not these people included vigorous dieting or exercise.  They also mention that Leptigen is an:

“effective way to assist your body”

No proof of this is provided anywhere. The clinical studies were on the individual ingredients and not on Leptigen as a whole. They make it seem as if customers report in to showcase their results, but no before and after photos are provided. Instead there are 6 written testimonials from people with a first name. It’s unknown if these people actually exist.

Flawed Clinical Studies

The company does offer clinical studies for the individual ingredients, but they’re not as useful as more current and larger studies.

They list a study for Green Tea Extract which showed it lead to:

“24-h expenditure and fat oxidation in humans”

This study was performed on just 10 healthy males within a 24 hour period. More widespread studies cited by trusted health organizations like the NCCIH showed that there are no weight loss properties in long term studies.

Testing for just a 24 hour period isn’t a useful exercise since it’s only with 10 people.

The caffeine study is also flawed since it was only tested between 100, 200, and 400 mg. Leptigen offers 75 mg in one serving, 150 mg in a full days’ worth.  So they never tested the full amount found in Leptigen the study also ended with the conclusion that:

“caffeine in the treatment of obesity remains to be determined”

So the study which was meant to show how effective caffeine is actually debunked their claims.

The reported clinical study on Meratrim might be biased since it mentions the money was paid by a:

“unrestricted grant from the InterHealth Nutraceuticals Inc.”

This is the same company that makes Meratrim; therefore more studies need to be performed by groups without a financial stake.

Finally there’s the report on ChromeMate which showed there needs to be:

“further study of the efficacy of chromium nicotinate”

So this study alone was not enough to prove whether or not ChromeMate has been tested enough.  More information needs to be done to show whether or not it’s actually useful for safe.

All the clinical studies provided by the company are flawed and some actually go against the weight loss claims the company suggests is possible.

Also, no clinical studies are offered on the full mixture of Leptigen. It’s unknown if it’s actually useful when used in its whole form.

Business of Leptigen

The company’s customer service can be reached through the following:

Phone Number: (800) 555-3951


They fail to add any official company name, however, when researching the address they provided it linked back to Triton Web Properties. They host and maintain websites of which many people traffic due to their common names.

It’s unknown if this is a coincidence or if the company is owned by this group.

One review online mentioned that they bought a product from this address and that it was a scam:

Scam! Fake products! 
No customer service and no returns!”

The company did not respond to this and it’s unknown how the company operates. Leptigen’s website claims that in house scientists formulated the ingredients in this product, but it’s unknown what kind of background in science they have. There’s also no studies listed by their own scientists.

Customer Opinions of Leptigen

There are a handful of online reviews available:

“gave me stomach aches and loose stools”

“What a joke of a product”

“total waste of money!”

“it seems like a shady company”

There were many opinions of people who experienced side effects such as jitters and insomnia. There’s also much concern about the company, with many claiming it’s a scam.

Customers also didn’t appreciate the mixture of ingredients; many felt it was greatly overpriced since many of these ingredients can be bought cheaper on their own.


Leptigen has many points to consider:

  • The ingredients are either common or they’re not yet proven: The company provides a proprietary blend that studies show has weak to no benefits. The effects of green tea have been shown to not be effective for weight loss. Though it’s added caffeine of which there’s 75 mg per serving may have an effect, it’s only short term and potentially side effect causing. Other ingredients include Meratrim which is a mixture of the unproven to be safe or effective mangosteen, and the under researched sphaeranthus indicus. Finally chromium and niacin mixed together has been under researched and even positive clinical studies mention more information is needed.
  • Many customers have complained about a lack of benefits: There have been complaints from people experiencing side effects and a lack of weight loss. The company does admit that mild headaches and rapid heart rate have been reported, but others’ have also added insomnia and jitters as side effects. There have also been people who mentioned they exercised and dieted and yet they still didn’t see weight loss.
  • There’s no proof for some of the additives: The ingredients added have been shown to be ineffective or requiring more studies according to clinical studies. Oddly enough, one of the studies provide by Leptigen actually showed that the added caffeine needed more studies to show whether or not it could help with weight loss. The other studies on the patented ChromeMate needed more studies, and Meratrims study was funded by the owners of the patent. More up to date research from unbiased groups mentions that the additives are greatly under researched. Mangosteen and green tea has not been proven to be safe or effective, caffeine can build a tolerance as well as side effects, and ChromeMate’s needs further research.
  • Information on the company is limited: The manufacturers claim to have in house scientists that worked to find a weight loss solution. What they came up with is Leptigen. However, these scientists never report any clinical studies on Leptigen. Usually scientists that study additives can provide their own proof when it comes to formulating a supplement. There’s never any proof to suggest that they actually have legitimate scientists. The company fails to provide any information about their practices, and their address goes back to a company that owns famous websites. It’s unknown how the company operates or if their money back return is actually useful.
  • No proof is provided that the entire mixture is safe or effective: One major problem with the brand is that its money back return policy is hard to understand. They claim a 120 day return for products that aren’t “overly used”. This can be interpreted in many ways. It’s unknown if this means that you can’t finish their bottles, or if they don’t allow returns on damaged products. This lack of clarification makes it hard to fit under their guidelines. At their own accord they can deny returns based off of these words. Therefore, it’s not a secure guarantee.

Not only have customers complained about side effects, but many have added that they didn’t experience any weight loss.

There’s also concern over the lack of quality clinical studies. Many of the individual studies on ingredients were either biased, not proven to be effective for weight loss, or incredibly flawed.

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